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Patricia A. Labosky, Ph.D.

Associate Professor

Phone: 615-322-2540
Fax: 615-343-2173
Email: trish.labosky@vanderbilt.edu

Internal website

Affiliations

Department of Cell and Developmental Biology
Program in Developmental Biology



Dr. Patricia A. Labosky joined the Vanderbilt Center for Stem Cell Biology (VCSCB) in September of 2006 as its second faculty recruit. Trish earned her Ph.D. from Wesleyan University, and did her postdoctoral training here at Vanderbilt University. She was an Assistant Professor at the University of Pennsylvania, until we successfully recruited her to Vanderbilt. Dr. Labosky's research focuses on studying genes that control normal development of the mammalian embryo. In particular is the Fox family transcription factors, such as Foxd3, which expresses ubiquitously in the early mouse embryo, and later in multipotent neural crest cells and the pancreas. Her studies are providing valuable new insights about the specification and maintenance of embryonic stem cells (ES Cells), and aim towards trying to understand the molecular control of stem cell fate.

Publications

PubMedID Citation
18653770 Liu Y, Labosky PA. Regulation of ES Cell Self Renewal and Pluripotency by Foxd3. (2008) Stem Cells :
18367558 Teng L, Mundell NA, Frist AY, Wang Q, Labosky PA. Requirement for Foxd3 in the maintenance of neural crest progenitors. (2008) Development 135: 1615-24
17092955 Steiner AB, Engleka MJ, Lu Q, Piwarzyk EC, Yaklichkin S, Lefebvre JL, Walters JW, Pineda-Salgado L, Labosky PA, Kessler DS. FoxD3 regulation of Nodal in the Spemann organizer is essential for Xenopus dorsal mesoderm development. (2006) Development 133: 4827-38
17076284 Teng L, Labosky PA. Neural crest stem cells. (2006) Adv Exp Med Biol 589: 206-12
16750430 Perera HK, Caldwell ME, Hayes-Patterson D, Teng L, Peshavaria M, Jetton TL, Labosky PA. Expression and shifting subcellular localization of the transcription factor, Foxd3, in embryonic and adult pancreas. (2006) Gene Expr Patterns 6: 971-7
16039639 Tompers DM, Foreman RK, Wang Q, Kumanova M, Labosky PA. Foxd3 is required in the trophoblast progenitor cell lineage of the mouse embryo. (2005) Dev Biol 285: 126-37
15153600 Tompers DM, Labosky PA. Electroporation of murine embryonic stem cells: a step-by-step guide. (2004) Stem Cells 22: 243-9
12381664 Hanna LA, Foreman RK, Tarasenko IA, Kessler DS, Labosky PA. Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo. (2002) Genes Dev 16: 2650-61
10662648 Kanzler B, Foreman RK, Labosky PA, Mallo M. BMP signaling is essential for development of skeletogenic and neurogenic cranial neural crest. (2000) Development 127: 1095-104
9767163 Labosky PA, Kaestner KH. The winged helix transcription factor Hfh2 is expressed in neural crest and spinal cord during mouse development. (1998) Mech Dev 76: 185-90

You can also view publications listed at PubMed.

VCSCB Faculty Investigators

Stacey S. Huppert
Assistant Professor
Patricia A. Labosky
Associate Professor
Mark A. Magnuson
Director


VCSCB Faculty Members

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