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Stacey S. Huppert, Ph.D.

Assistant Professor

Phone: 615-343-4024
Fax: 615-322-6645
Email: stacey.huppert@vanderbilt.edu

Internal website

Affiliations

Department of Cell and Developmental Biology
Program in Developmental Biology
Digestive Disease Research Center

Dr. Stacey S. Huppert joined the Vanderbilt Center for Stem Cell Biology (VCSCB) in October of 2005 as its first faculty recruit. Stacey earned her doctorate in genetics from Indiana University in the Laboratory of Marc A. T. Muskavitch. Her thesis work demonstrated that Notch signaling exerts feedback regulation on ligand and receptor expression, and that the resultant asymmetries underlie proper cell fate determination. She continued to study Notch signaling mechanisms with Raphael Kopan, first as a postdoctoral fellow, then as an Instructor in the Department of Molecular Biology and Pharmacology at Washington University School of Medicine. Dr. Huppert’s research program will focus on exploring how intercellular signaling pathways are integrated in both developmental and disease responses of the liver. She will explore the role of Notch in liver organogenesis and regeneration in order to better understand the role of progenitor/stem cells in hepatocyte cell population maintenance and renewal.

Publications

PubMedID Citation
18354499 Knutson SK, Chyla BJ, Amann JM, Bhaskara S, Huppert SS, Hiebert SW. Liver-specific deletion of histone deacetylase 3 disrupts metabolic transcriptional networks. (2008) EMBO J 27: 1017-28
17215306 Vooijs M, Ong CT, Hadland B, Huppert S, Liu Z, Korving J, van den Born M, Stappenbeck T, Wu Y, Clevers H, Kopan R. Mapping the consequence of Notch1 proteolysis in vivo with NIP-CRE. (2007) Development 134: 535-44
16300632 Chandu D, Huppert SS, Kopan R. Analysis of transmembrane domain mutants is consistent with sequential cleavage of Notch by gamma-secretase. (2006) J Neurochem 96: 228-35
15866159 Huppert SS, Ilagan MX, De Strooper B, Kopan R. Analysis of Notch function in presomitic mesoderm suggests a gamma-secretase-independent role for presenilins in somite differentiation. (2005) Dev Cell 8: 677-88
15354292 Nichols AM, Pan Y, Herreman A, Hadland BK, De Strooper B, Kopan R, Huppert SS. Notch pathway is dispensable for adipocyte specification. (2004) Genesis 40: 40-4
15251982 Hadland BK, Huppert SS, Kanungo J, Xue Y, Jiang R, Gridley T, Conlon RA, Cheng AM, Kopan R, Longmore GD. A requirement for Notch1 distinguishes 2 phases of definitive hematopoiesis during development. (2004) Blood 104: 3097-105
11709178 Huppert S, Kopan R. Regulated intramembrane proteolysis takes another twist. (2001) Dev Cell 1: 590-2
10879540 Huppert SS, Le A, Schroeter EH, Mumm JS, Saxena MT, Milner LA, Kopan R. Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1. (2000) Nature 405: 966-70
9310323 Huppert SS, Jacobsen TL, Muskavitch MA. Feedback regulation is central to Delta-Notch signalling required for Drosophila wing vein morphogenesis. (1997) Development 124: 3283-91
9178257 Parks AL, Huppert SS, Muskavitch MA. The dynamics of neurogenic signalling underlying bristle development in Drosophila melanogaster. (1997) Mech Dev 63: 61-74

You can also view publications listed at PubMed.

VCSCB Faculty Investigators

Stacey S. Huppert
Assistant Professor
Patricia A. Labosky
Associate Professor
Mark A. Magnuson
Director


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