Events -- VCSCB/CDB Seminar Series

Notch Signaling in Mice

Tom Gridley, Ph.D.
Senior Staff Scientist
The Jackson Laboratory

The Notch signaling pathway is an evolutionarily conserved intercellular signaling mechanism, and mutations in Notch pathway components disrupt embryonic development in diverse organisms and cause inherited disease syndromes and cancers in humans. My laboratory has been performing a comprehensive genetic analysis of the requirements for Notch pathway components during embryonic development in mice, as well as developing mouse models of inherited disease syndromes caused by mutations of Notch pathway ligands and receptors. Current work on analysis of the functional roles of the Notch pathway during embryonic heart and blood vessel development, and the analysis of Notch pathway function during oocyte development, will be described.

About this ongoing activity:

The Vanderbilt Center for Stem Cell Biology (VCSCB) sponsors a monthly seminar series in conjunction with the Department of Cell ; Developmental Biology's Monday Seminar Series for all Vanderbilt faculty, research assistants and students on topics relating to developmental and stem cell biology. VCSCB seminars are held on Mondays from 12:15-1:15 PM in 1220 MRB-III.