Events -- VCSCB/CDB Seminar Series

CANCELED

Celeste Simon, Ph.D.
Professor, Dept. of Cell and Developmental Biology
Investigator, Howard Hughes Medical Institute
Abramson Family Cancer Research Institute
University of Pennsylvania Cancer Center

We have hypothesized that changes in oxygen availability would influence stem cell quiescence, maintenance, proliferation, differentiation, and migration. I will present recent data showing that this hypothesis is correct and holds true for hematopoietic stem cells, placental stem cells, and of note, the neuronal stem cells of the adult brain. This is because critical pathways, such as Oct4, Wnt, Notch, and myc are also oxygen sensitive and modulated by pathways regulated by hypoxia inducible factors (HIFs). I will also discuss our future directions in clarifying this novel hypothesis showing that oxygen not only generates intracellular ATP and is an important electronic septor in multiple biochemical pathways but actually functions as a developmental morphogen.

About this ongoing activity:

The Vanderbilt Center for Stem Cell Biology (VCSCB) sponsors a monthly seminar series in conjunction with the Department of Cell ; Developmental Biology's Monday Seminar Series for all Vanderbilt faculty, research assistants and students on topics relating to developmental and stem cell biology. VCSCB seminars are held on Mondays from 12:15-1:15 PM in 1220 MRB-III.